Lymphoma is cancer that begins in infection-fighting cells of the immune system, called lymphocytes. These cells are in the lymph nodes, spleen, thymus, bone marrow, and other parts of the body. When you have lymphoma, lymphocytes change and grow out of control.

There are two main types of lymphoma:

Non-Hodgkin and Hodgkin lymphoma involve different types of lymphocyte cells. Every type of lymphoma grows at a different rate and responds differently to treatment.

Lymphoma is very treatable, and the outlook can vary depending on the type of lymphoma and its stage. Your doctor can help you find the right treatment for your type and stage of the illness.

Lymphoma is different from leukemia. Each of these cancers starts in a different type of cell.

Lymphoma starts in infection-fighting lymphocytes.

Leukemia starts in blood-forming cells inside bone marrow.

Lymphoma is also not the same as lymphedema, which is a collection of fluid that forms in body tissues when there is damage or blockage to the lymph system.

Causes

• Are in your 60s or older for non-Hodgkin lymphoma
• Are between 15 and 40 or older than 55 for Hodgkin lymphoma
• Are male, although certain subtypes may be more common in females
• Have a weak immune system from HIV/AIDS, an organ transplant, or because you were born with an immune disease
• Have an immune system disease such as rheumatoid arthritis, Sjögren's syndrome, lupus, or celiac disease
• Have been infected with a virus such as Epstein-Barr, hepatitis C, or human T-cell leukemia/lymphoma (HTLV-1)
• Have a close relative who had lymphoma
• Were exposed to benzene or chemicals that kill bugs and weeds
• Were treated for Hodgkin or non-Hodgkin lymphoma in the past
• Were treated for cancer with radiation

Symptoms

• Swollen glands (lymph nodes), often in the neck, armpit, or groin that are painless
• Cough
• Shortness of breath
• Fever
• Night sweats
• Fatigue
• Weight loss
• Itching

Diagnosis

Bone marrow aspiration or biopsy: Your doctor uses a needle to remove fluid or tissue from your bone marrow -- the spongy part inside bone where blood cells are made -- to look for lymphoma cells.

Chest X-ray: It will be done using low doses of radiation radiation to make images of the inside of your chest.

MRI: A technician will use powerful magnets and radio waves to make pictures of organs and structures inside your body.

PET scan: This imaging test uses a radioactive substance to look for cancer cells in your body.

Molecular test: This test is used to find changes to genes, proteins, and other substances in cancer cells to help your doctor figure out which type of lymphoma you have.

Blood tests: These check the number of certain cells, levels of other substances, or evidence of infection in your blood.

Chemotherapy

Chemotherapy, which uses drugs to kill cancer cells

Radiation therapy, which uses high-energy rays to destroy cancer cells

Immunotherapy, which uses your body's immune system to attack cancer cells

Targeted therapy that targets aspects of lymphoma cells to curb their growth

CONCLUSION

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Journal of Molecular Oncology Research
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